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ea0070aep569 | Pituitary and Neuroendocrinology | ECE2020

Difference in plasma miRNA levels in inferior petrosal sinus samples from patients with ACTH-dependent Cushing’s syndrome as assessed by next-generation sequencing (NGS).

Belaya Zhanna , Malygina Anastasia , Nikitin Alexey , Koshkin Philipp , Sitkin Ivan , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan

Introduction: ACTH-secreting pituitary adenoma tissue differs from normal pituitary gland tissue in microRNA (miR) expression. MiRs are secreted into circulation and can be detected as potential biomarkersAim: To evaluate the difference in miR levels in plasma samples drained from inferior petrosal sinuses in patients with Cushing’s disease (CD) and ectopic-ACTH syndrome (EAS).Materials and methods: we enrolled 24 patients wi...

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ea0081ep642 | Pituitary and Neuroendocrinology | ECE2022

Circulating plasma microRNA in patients with ACTH-dependent cushing’s syndrome.

Malygina Anastasia , Belaya Zhanna , Solodovnikov Alexander , Nikitin Alexey , Koshkin Philipp , Sitkin Ivan , Pikunov Michael , Khandaeva Patimat , Lutsenko Alexander , Trukhina Diana , Lapshina Anastasia , Grigoriev Andrey , Melnichenko Galina , Dedov Ivan

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushings diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushings syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...

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Endocrine Abstracts

Difference in plasma miRNA levels in inferior petrosal sinus samples from patients with ACTH-dependent Cushing’s syndrome as assessed by next-generation sequencing (NGS).

Circulating plasma microRNA in patients with ACTH-dependent cushing’s syndrome.

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